| dc.contributor.author | Sumlu, Esra | |
| dc.contributor.author | Bostanci, Aykut | |
| dc.contributor.author | Sadi, Gokhan | |
| dc.contributor.author | Alcigir, Mehmet Eray | |
| dc.contributor.author | Akar, Fatma | |
| dc.date.accessioned | 2021-01-14T18:10:51Z | |
| dc.date.available | 2021-01-14T18:10:51Z | |
| dc.date.issued | 2020 | |
| dc.identifier.citation | Bu makale açık erişimli değildir. | en_US |
| dc.identifier.issn | 1381-3455 | |
| dc.identifier.issn | 1744-4160 | |
| dc.identifier.uri | https://doi.org/10.1080/13813455.2020.1727527 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12587/12797 | |
| dc.description | Bostanci, Aykut/0000-0002-6855-0645; Sumlu, Esra/0000-0002-5004-5958; Sadi, Gokhan/0000-0002-6422-1203 | en_US |
| dc.description | WOS:000514727100001 | en_US |
| dc.description | PubMed: 32067511 | en_US |
| dc.description.abstract | In the present study, we investigated the influence of Lactobacillus plantarum and Lactobacillus helveticus supplementation on lipogenesis, insulin signalling and glucose transporters in liver of high-fructose-fed rats. Fructose was given to the rats as a 20% solution in drinking water for 15 weeks. Lactobacillus plantarum and L. helveticus supplementations were performed by gastric gavage once a day during final 6 weeks. Dietary high-fructose increased hepatic weight, lipid accumulation and FASN expression as well as caused a significant reduction in IRS-1 expression, pAKT/total AKT and peNOS/total eNOS ratios, but an elevation in GLUT2 and GLUT5 mRNAs in the liver. Lactobacillus plantarum supplementation decreased hepatic weight, triglyceride content and FASN expression as well as improved IRS-1/AKT/eNOS pathway and GLUT2 expression in the liver of high-fructose-fed rats. However, L. helveticus supplementation exerted a restoring effect on lipid accumulation by decreasing FASN expression, and regulating effect on IRS-1 and GLUT2 expressions. | en_US |
| dc.description.sponsorship | Gazi University Research FundGazi University [02/2018-14] | en_US |
| dc.description.sponsorship | This study was supported by grants from the Gazi University Research Fund under Grant [02/2018-14]. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | TAYLOR & FRANCIS LTD | en_US |
| dc.relation.isversionof | 10.1080/13813455.2020.1727527 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Dietary fructose | en_US |
| dc.subject | fatty liver | en_US |
| dc.subject | insulin signalling | en_US |
| dc.subject | Lactobacillus plantarum | en_US |
| dc.subject | Lactobacillus helveticus | en_US |
| dc.title | Lactobacillus plantarum improves lipogenesis and IRS-1/AKT/eNOS signalling pathway in the liver of high-fructose-fed rats | en_US |
| dc.type | article | en_US |
| dc.contributor.department | KKÜ | en_US |
| dc.relation.journal | ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
