The Effect of Treatment on Endothelin-1 Concentration and Mean Arterial Pressure in Preeclampsia and Eclampsia

Abstract

Objective: The aim of this study was to determine the effect of treatment on endotelin-1 concentration that is considered to have role in etiopathogenesis of eclampsia and preeclampsia. Methods: Nine patients with eclampsia and 12 patients with preeclampsia were included to the study. Endothelin-1 levels were measured before and after magnesium sulfate treatment. After the magnesium sulfate administration, if the blood pressure was still elevated, nifedipine was given. Results: Endothelin-1 levels of preeclamptic patients before and after magnesium sulfate treatment were 16.9±2.3 fmol/ml and 14.6±1.9 fmol/ml respectively (P<0.05). The same measurements of eclamptic patients were 18.1±3.2 and 14.7±3.4 respectively (P<0.05). The mean blood pressures of preeclamptic patients before and after magnesium sulfate were 125.8±7.3 mm-Hg, 118.2±8. 7 mm-Hg respectively, and the same measurements of eclamptic patients were 136.0±12.4 mm-Hg and 123.1±10.6 mm-Hg respectively (P<0.05, P<0.05). Conclusion: Treatment had been found to have negative effects on endothelin-1 levels that is considered to play an important role on etiopathogenesis of eclampsia and preeclampsia.