dc.contributor.author | Bozdogan, O | |
dc.contributor.author | Erkek, E | |
dc.contributor.author | Atasoy, P | |
dc.contributor.author | Kocak, M | |
dc.contributor.author | Birol, A | |
dc.contributor.author | Caydere, M | |
dc.date.accessioned | 2020-06-25T17:34:57Z | |
dc.date.available | 2020-06-25T17:34:57Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0001-5555 | |
dc.identifier.uri | https://doi.org/10.1080/000155502762064548 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/2961 | |
dc.description | WOS: 000180345700004 | en_US |
dc.description | PubMed: 12575847 | en_US |
dc.description.abstract | Aberrant expression of bcl-gene products has been implicated in the development of non-melanoma skin cancers. Recently, altered expression of alpha-smooth muscle actin has been proposed as predictive of tumour behaviour in basal cell carcinomas. The purpose of this study was to compare the aggressive and non-aggressive basal cell carcinomas in terms of bcl-gene products and alpha-smooth muscle actin expression. Fifty excisional biopsy samples were studied by immunohistochemical technique for the differential expressions of bcl-2, bax, bcl-x and alpha-smooth muscle actin. Bcl-2, bcl-x and bax were expressed in 34 (68%), 38 (76%) and 41 (82%) specimens, respectively. Immunoreactivity for alpha-smooth muscle actin was noted both in tumour nests (64%) and within the stroma (54%). There was a significant difference between aggressive and non-aggressive basal cell carcinomas in terms of bcl-2 and stromal alpha-smooth muscle actin immunoreactivity. Non-aggressive basal cell carcinomas display a concordant expression of bcl-family proteins, whereas aggressive tumours reveal a discordant pattern. An increased expression of stromal alpha-smooth muscle actin with a concomitant decrease or loss of bcl-2 expression may be highly suggestive of aggressiveness in basal cell carcinoma. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis As | en_US |
dc.relation.isversionof | 10.1080/000155502762064548 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | basal cell carcinoma | en_US |
dc.subject | amyloid | en_US |
dc.subject | apoptosis | en_US |
dc.subject | bcl-2 | en_US |
dc.subject | bax | en_US |
dc.subject | bcl-x | en_US |
dc.subject | myofibroblast | en_US |
dc.title | Bcl-2-related proteins, (alpha)-smooth muscle actin and amyloid deposits in aggressive and non-aggressive basal cell carcinomas | en_US |
dc.type | article | en_US |
dc.contributor.department | Kırıkkale Üniversitesi | en_US |
dc.identifier.volume | 82 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 423 | en_US |
dc.identifier.endpage | 427 | en_US |
dc.relation.journal | Acta Dermato-Venereologica | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |