dc.contributor.author | Tombul, Mustafa | |
dc.contributor.author | Bulut, Adnan | |
dc.contributor.author | Turk, Mustafa | |
dc.contributor.author | Ucar, Busra | |
dc.contributor.author | Isilar, Ozer | |
dc.date.accessioned | 2020-06-25T18:23:52Z | |
dc.date.available | 2020-06-25T18:23:52Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | closedAccess | en_US |
dc.identifier.issn | 2470-1556 | |
dc.identifier.issn | 2470-1564 | |
dc.identifier.uri | https://doi.org/10.1080/15533174.2016.1218510 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/7208 | |
dc.description | WOS: 000396521300012 | en_US |
dc.description.abstract | Due to the fact that ferrocene and furan derivatives have long been known to be one of the most biologically active compounds, preparation of their new derivatives might serve a very important purpose. Herein, five furoyl ferrocenes were synthesized via EAS reaction utilizing AlCl3-EtAlCl2 Lewis acids. The compounds 1-5 were obtained in moderate yields and characterized by IR, H-1-NMR, C-13-NMR, and mass spectrometry. Although toxicity increases with concentration, at 100 mu g/mL concentration, the protection of cell viability was observed to be 70% level. At 50 mg/mL concentration, apoptosis in cancer cells observed was 63 +/- 4% leading to high apoptosis ratio for the compound 3. For the compounds (1-5), the necrotic effects were found to be between 21% and 39% at 50 mu g/mL concentration. | en_US |
dc.description.sponsorship | Kirikkale University Scientific Research Centre (Kirikkale BAP)Kirikkale University [2009-39] | en_US |
dc.description.sponsorship | The authors gratefully acknowledge the financial support from the Kirikkale University Scientific Research Centre (Kirikkale BAP Grant no: 2009-39). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Inc | en_US |
dc.relation.isversionof | 10.1080/15533174.2016.1218510 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Ferrocene | en_US |
dc.subject | furan | en_US |
dc.subject | biological activity | en_US |
dc.subject | cytotoxicity | en_US |
dc.subject | synthesis | en_US |
dc.title | Synthesis and biological activity of ferrocenyl furoyl derivatives | en_US |
dc.type | article | en_US |
dc.contributor.department | Kırıkkale Üniversitesi | en_US |
dc.identifier.volume | 47 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 865 | en_US |
dc.identifier.endpage | 869 | en_US |
dc.relation.journal | Inorganic And Nano-Metal Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |