dc.contributor.author | Kang, Mijeong | |
dc.contributor.author | Kim, Eunkyoung | |
dc.contributor.author | Temocin, Zulftkar | |
dc.contributor.author | Li, Jinyang | |
dc.contributor.author | Dadachova, Ekaterina | |
dc.contributor.author | Wang, Zheng | |
dc.contributor.author | Payne, Gregory F. | |
dc.date.accessioned | 2020-06-25T18:29:25Z | |
dc.date.available | 2020-06-25T18:29:25Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | closedAccess | en_US |
dc.identifier.issn | 0897-4756 | |
dc.identifier.issn | 1520-5002 | |
dc.identifier.uri | https://doi.org/10.1021/acs.chemmater.8b02428 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/7308 | |
dc.description | Temocin, Zulfikar/0000-0001-7151-9772; Panzella, Lucia/0000-0002-2662-8205; Payne, Gregory/0000-0001-6638-9459 | en_US |
dc.description | WOS: 000444792800003 | en_US |
dc.description.abstract | Melanins are ubiquitous in nature, yet their functions remain poorly understood, because their structures and properties elude characterization by conventional methods. Since many of the proposed functions of melanins (e.g., antioxidant, pro-oxidant, and radical scavenging) involve an exchange of electrons, we developed an electrochemical reverse engineering methodology to probe the redox properties of melanin. This mediated electrochemical probing (MEP) method (i) characterizes insoluble melanin particles that are localized adjacent to an electrode within a permeable hydrogel film, (ii) employs diffusible mediators to shuttle electrons between the electrode and melanin sample, and (iii) imposes complex sequences of input voltages and analyzes output response characteristics (e.g., currents) to reveal redox properties. Here, we illustrate the versatility of MEP and review results demonstrating that melanins have reversible redox activities, can exchange electrons with various reductants and oxidants, and can quench radicals either by donating or accepting electrons. These results suggest possible biological functionalities for melanin and motivate the use of MEP for characterizing additional (i.e., synthesized) materials whose functions rely on redox properties. More broadly, MEP is revealing a richness to redox activities that has previously been inaccessible to investigation. | en_US |
dc.description.sponsorship | United States National Science FoundationNational Science Foundation (NSF) [DMREF-1435957]; Department of Defense (Defense Threat Reduction Agency)United States Department of DefenseDefense Threat Reduction Agency [HDTRA1-13-1-0037, HDTRA1-15-1-0058] | en_US |
dc.description.sponsorship | The authors gratefully acknowledge financial support from the United States National Science Foundation (No. DMREF-1435957) and the Department of Defense (Defense Threat Reduction Agency; Nos. HDTRA1-13-1-0037 and HDTRA1-15-1-0058). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Amer Chemical Soc | en_US |
dc.relation.isversionof | 10.1021/acs.chemmater.8b02428 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.title | Reverse Engineering To Characterize Redox Properties: Revealing Melanin's Redox Activity through Mediated Electrochemical Probing | en_US |
dc.type | article | en_US |
dc.contributor.department | Kırıkkale Üniversitesi | en_US |
dc.identifier.volume | 30 | en_US |
dc.identifier.issue | 17 | en_US |
dc.identifier.startpage | 5814 | en_US |
dc.identifier.endpage | 5826 | en_US |
dc.relation.journal | Chemistry Of Materials | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |