dc.contributor.author | Tatar, T. | |
dc.contributor.author | Polat, Y. | |
dc.contributor.author | Comu, F. M. | |
dc.contributor.author | Kartal, H. | |
dc.contributor.author | Arslan, M. | |
dc.contributor.author | Kucuk, A. | |
dc.date.accessioned | 2020-06-25T18:29:58Z | |
dc.date.available | 2020-06-25T18:29:58Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Tatar T, Polat Y, Comu FM, Kartal H, Arslan M, Kucuk A. Effect of cerium oxide on erythrocyte deformability in rat lower extremity ischemia reperfusion injury. Bratisl Lek Listy. 2018;119(7):441-443. | en_US |
dc.identifier.issn | 0006-9248 | |
dc.identifier.issn | 1336-0345 | |
dc.identifier.uri | https://doi.org/10.4149/BLL_2018_080 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/7518 | |
dc.description | Arslan, Mustafa/0000-0003-4882-5063; KARTAL, HAKAN/0000-0003-4539-0228 | en_US |
dc.description | WOS: 000440978000008 | en_US |
dc.description | PubMed: 30160134 | en_US |
dc.description.abstract | BACKGROUND: Cerium oxide is the oxide form of cerium, which has protective effects in ischemia reperfusion (I/R) injury. The purpose of our study was to look into the effects of this rare-earth metal on erythrocyte deformability in rat lower extremity I/R injury model. MATERIALS AND METHODS: We used 24 Wistar albino rats as subjects in our study. They were divided into 4 groups; randomized control group (group C; n = 6), cerium oxide group 0.5 mg.kg(-1), intraperitoneal (group CO; n = 6), I/R group (group I/R; n = 6) and I/R group with cerium oxide 0.5 mg.kg(-1) intraperitoneally (group I/R-CO; n = 6). Erythrocyte packs were prepared from heparinized blood samples and deformability measurements were performed. RESULTS: We obtained similar results from the control and I/R-CO groups (p = 0.158). The results in I/R group were evidently higher than those of the control, CO, and IR-CO groups (p < 0.0001, p < 0.0001, p = 0.001, respectively). CONCLUSION: We detected unfavorable effects of I/R on erythrocyte deformability, which may impair blood flow and hence tissue perfusion in infrarenal rat aorta. We also found that cerium oxide had beneficial effects by reversing undesirable effects of I/R. Further studies with larger volume are required to support our promising results (Fig. 1, Ref. 24). Text in PDF www.elis.sk. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Comenius Univ | en_US |
dc.relation.isversionof | 10.4149/BLL_2018_080 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | erythrocyte deformability | en_US |
dc.subject | ischemia reperfusion | en_US |
dc.subject | cerium oxide | en_US |
dc.subject | rat | en_US |
dc.title | Effect of cerium oxide on erythrocyte deformability in rat lower extremity ischemia reperfusion injury | en_US |
dc.type | article | en_US |
dc.contributor.department | Kırıkkale Üniversitesi | en_US |
dc.identifier.volume | 119 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 441 | en_US |
dc.identifier.endpage | 443 | en_US |
dc.relation.journal | Bratislava Medical Journal-Bratislavske Lekarske Listy | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |