The effects of ACE gene polymorphism on the serum antioxidant capacity

Abstract

The association between angiotensin converting enzyme (ACE) gene polymorphism serum total sulfhydryl groups (Total SH), nitric oxide (NO) and malonyldialdehyde (MDA) levels and coronary artery disease (CAD) was already shown by the studies. In this study, we aimed to investigate the effects of ACE polymorphism on the serum total SH groups, NO and MDA levels in patients with and without CAD. A total of 146 participants (71 male, mean age: 56.0 ± 11.9 years; 75 female, mean age: 57.1 ± 13.5 years) were enrolled into the study. All the patients were performed coronary angiography. The associations between ACE genotypes (DD,ID,II) and coronary artery disease were evaluated by statistically methods. We determined that there was statistically significant differences about the serum levels of NO, total SH and MDA among ACE genotypes in the patients without CAD (One Way ANOVA, P=0.005, P=0.004 and p<0.001, respectively). Only total SH levels was of statistically significant difference among ACE genotypes in the patients with CAD(One Way ANOVA, P=0.034) In conclusion we determined that there were significant differences about serum total antioxidant capacity, MDA and NO levels among ACE (I/D) genotypes.