Plasma adrenomedullin levels in patients with polycystic ovary syndrome

Abstract

Objective: To evaluate adrenomedullin levels in patients. with polycystic ovary syndrome (PCOS). Design: Prospective study. Setting: Department of obstetrics and gynecology in a university hospital. Patient(s): Thirty-eight women with PCOS and 29 healthy control subjects were enrolled in the study. Intervention(s): Plasma. adrenomedullin, serum androstenedione, free T, T, DHEAS, SHBG, thyrotropin, PRL, FSH, LH, and E-2 were measured in each subject. Insulin resistance was estimated by fasting insulin level, fasting glucose:insulin ratio and 75-g glucose tolerance test for 2 hours. Main Outcome Measure(s): Plasma adrenomedullin levels and, correlations among adrenomullin and gonadotropins , female sex steroids, androgens, and insulin resistance. Result(s): There was no significant difference concerning plasma adrenomullin concentrations between the groups. In patients with PCOS, fasting glucose, fasting insulin, body mass index, and free T were inversely 179 y correlated with glue correlated with the plasma adrenomedullin. Plasma adrenomedullin was significantly correlated with glucose: insulin ratio. After controlling for, body mass index, there were no significant correlations between the above-mentioned parameters. Conclusion(s): Adrenomedullin may play a role in regulating the insulin metabolism in patients with PCOS.