dc.contributor.author | Agalar, C | |
dc.contributor.author | Ozdogan, M | |
dc.contributor.author | Agalar, F | |
dc.contributor.author | Saygun, O | |
dc.contributor.author | Aydinuraz, K | |
dc.contributor.author | Akkus, A | |
dc.contributor.author | Akturk, S | |
dc.date.accessioned | 2020-06-25T17:43:33Z | |
dc.date.available | 2020-06-25T17:43:33Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 1445-1433 | |
dc.identifier.uri | https://doi.org10.1111/j.1445-2197.2006.03728.x | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/3791 | |
dc.description | WOS: 000237738500023 | en_US |
dc.description | PubMed: 16768701 | en_US |
dc.description.abstract | Background: The aim of this study was to constitute a valid graft infection model with Staphylococcus epidermidis in rats. Method: Rats were divided into seven groups. In groups 1 and 2, 2 cm x 2 cm polypropylene grafts were incubated with 10(8) c.f.u./mL slime-positive S. epidermidis at 37 degrees C for 2 and 24 h and were then placed subfascially to the groins of rats. In the third group, naive grafts were placed and 0.5 mL of 3 x 10(7) c.f.u. slime-positive S. epidermidis were injected on the inside of the wounds. Rifampicin (30 mg/kg) in group 4 and teicoplanin (20 mg/kg) in group 5 were applied i.p. to rats with 2-h incubated grafts for prophylaxis. The same prophylactic regimens were given to groups 6 and 7 in which rats were incubated for 24 h. At eighth day, rats were killed and wounds were assessed with macroscopic evaluation and cultures. Results: No death occurred in any of the groups. In groups 1 and 2, 100% infection rates were achieved. However, graft infection was detected in only two (20%) of the rats in group 3 (P = 0.001). Prophylactic application of teicoplanin or rifampicin decreased the infection rates significantly in the short-incubation groups. Conclusion: Incubation of polypropylene grafts with slime-producing S. epidermidis for 2 and 24 h in the pre-application period achieved the occurrence of a standardized graft infection. Prophylactic use of teicoplanin and rifampicin decreased the infection rates. We propose to use this reproducible and reliable animal model of graft infection in future studies. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Blackwell Publishing | en_US |
dc.relation.isversionof | 10.1111/j.1445-2197.2006.03728.x | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | foreign body infection | en_US |
dc.subject | graft | en_US |
dc.subject | hernia | en_US |
dc.subject | polypropylene | en_US |
dc.subject | Staphylococcus epidermidis | en_US |
dc.title | A rat model of polypropylene graft infection caused by Staphylococcus epidermidis | en_US |
dc.type | article | en_US |
dc.identifier.volume | 76 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 387 | en_US |
dc.identifier.endpage | 391 | en_US |
dc.relation.journal | Anz Journal Of Surgery | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |