dc.contributor.author | Sahiner, Nurettin | |
dc.contributor.author | Sagbas, Selin | |
dc.contributor.author | Turk, Mustafa | |
dc.date.accessioned | 2020-06-25T18:12:14Z | |
dc.date.available | 2020-06-25T18:12:14Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0141-8130 | |
dc.identifier.issn | 1879-0003 | |
dc.identifier.uri | https://doi.org/10.1016/j.ijbiomac.2014.02.012 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/5819 | |
dc.description | Sagbas Suner, Selin/0000-0002-3524-0675; Sahiner, Nurettin/0000-0003-0120-530X | en_US |
dc.description | WOS: 000335201900031 | en_US |
dc.description | PubMed: 24583047 | en_US |
dc.description.abstract | Crosslinked p( sucrose) micro particles were synthesized for the first time from sucrose in water-in-oil microemulsion. Using divinyl sulfone (DVS) as crosslinker via reverse micelles of sodium bis(2-ethylhexyl) sulfosuccinate (AOT) p(sucrose) micro particles formed in a single step with very high yield (>90%). The particles have wide size distributions, and negative zeta potential, -27.30 mV, and can be made magnetic field responsive. P(sucrose) particles were shown to be degradable at pHs of 2.5 and 11. Dopamine and gallic acid were used as model drugs for absorption/release studies from p(sucrose) particles. Interestingly, it was shown that p(sucrose) microparticles can be a nutrient for Escherichia coli, and maybe used as a growth medium for other cells, bacteria and organisms. Additionally, the cytotoxic effect of p(sucrose) particles were determined as 26 and 32.5% dead cells against MDA MB-231 cancerous cells and L929 fibroblast cells at 100 ug/ml concentration, respectively. P(sucrose) particles can be safely used for in vivo applications. (C) 2014 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | Turkish Academy of ScienceTurkish Academy of Sciences | en_US |
dc.description.sponsorship | N. Sahiner is grateful to the Turkish Academy of Science for partial support under 2008 TUBA-GEBIP program. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.ijbiomac.2014.02.012 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Poly(sucrose) particle | en_US |
dc.subject | Microgel/nanogel | en_US |
dc.subject | Drug delivery | en_US |
dc.title | Poly(sucrose) micro particles preparation and their use as biomaterials | en_US |
dc.type | article | en_US |
dc.contributor.department | Kırıkkale Üniversitesi | en_US |
dc.identifier.volume | 66 | en_US |
dc.identifier.startpage | 236 | en_US |
dc.identifier.endpage | 244 | en_US |
dc.relation.journal | International Journal Of Biological Macromolecules | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |