dc.contributor.author | Costa-Pinto, Ana R. | |
dc.contributor.author | Vargel, I. | |
dc.contributor.author | Tuzlakoglu, K. | |
dc.contributor.author | Correlo, V. M. | |
dc.contributor.author | Sol, P. C. | |
dc.contributor.author | Faria, S. | |
dc.contributor.author | Neves, Nuno M. | |
dc.date.accessioned | 2020-06-25T18:12:14Z | |
dc.date.available | 2020-06-25T18:12:14Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | closedAccess | en_US |
dc.identifier.issn | 0885-3282 | |
dc.identifier.issn | 1530-8022 | |
dc.identifier.uri | https://doi.org/10.1177/0885328213512385 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/5826 | |
dc.description | Bayram, Cem/0000-0001-8717-4668; Faria, Susana/0000-0001-8014-9902; Correlo, Vitor M/0000-0002-5516-7583; Neves, Nuno M/0000-0003-3041-0687; Reis, Rui L. L/0000-0002-4295-6129; Sol, Paula/0000-0003-0512-0928; Costa-Pinto, Ana Rita/0000-0002-4764-8539; UMinho, 3B's Research Group/0000-0002-5195-3456; Tuzlakoglu, Kadriye/0000-0002-7564-9213 | en_US |
dc.description | WOS: 000334636700014 | en_US |
dc.description | PubMed: 24255003 | en_US |
dc.description.abstract | To understand the role of chitosan in chitosan-poly(butylene succinate) scaffolds (50% wt), 50%, 25%, and 0% of chitosan were used to produce different scaffolds. These scaffolds were invitro seeded and cultured with human bone marrow stromal cells in osteogenic conditions, revealing that higher percentage of chitosan showed enhanced cell viability over time, adhesion, proliferation, and osteogenic differentiation. Scaffolds were also implanted in cranial defects and iliac submuscular region in Wistar rats, and the results evidenced that chitosan-containing scaffolds displayed mild inflammatory response and good integration with surrounding tissues, showed by connective tissue colonization and the presence of new blood vessels. Scaffolds without chitosan-evidenced necrotic tissue in scaffolds' interior, proving that chitosan exerts a positive effect over cell behavior and displays a milder host inflammatory response invivo. | en_US |
dc.description.sponsorship | European Network of Excellence EXPERTISSUES [NMP3-CT-2004-500283]; Maxbone FCT [PTDC/SAU-ENB/115179/2009]; Portuguese research council "Fundacao para a Ciencia e a Tecnologia" (FCT)Portuguese Foundation for Science and Technology [SFRH/24735/2005] | en_US |
dc.description.sponsorship | This work was partially supported by the European Network of Excellence EXPERTISSUES (NMP3-CT-2004-500283) and Maxbone FCT funded project (PTDC/SAU-ENB/115179/2009). Ana Costa-Pinto was supported by the scholarship SFRH/24735/2005 from the Portuguese research council "Fundacao para a Ciencia e a Tecnologia" (FCT). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Sage Publications Ltd | en_US |
dc.relation.isversionof | 10.1177/0885328213512385 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | biomaterials | en_US |
dc.subject | tissue engineering | en_US |
dc.subject | regenerative medicine | en_US |
dc.subject | Chitosan | en_US |
dc.subject | scaffolds | en_US |
dc.title | Influence of scaffold composition over invitro osteogenic differentiation of hBMSCs and invivo inflammatory response | en_US |
dc.type | article | en_US |
dc.contributor.department | Kırıkkale Üniversitesi | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.startpage | 1430 | en_US |
dc.identifier.endpage | 1442 | en_US |
dc.relation.journal | Journal Of Biomaterials Applications | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |