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dc.contributor.authorKaradag, Ayse S.
dc.contributor.authorUzuncakmak, Tugba K.
dc.contributor.authorOzkanli, Seyma
dc.contributor.authorOguztuzun, Serpil
dc.contributor.authorMoran, Busra
dc.contributor.authorAkbulak, Ozge
dc.contributor.authorAkdeniz, Necmettin
dc.date.accessioned2020-06-25T18:23:13Z
dc.date.available2020-06-25T18:23:13Z
dc.date.issued2017
dc.identifier.citationclosedAccessen_US
dc.identifier.issn0011-9059
dc.identifier.issn1365-4632
dc.identifier.urihttps://doi.org/10.1111/ijd.13343
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7045
dc.descriptionUzuncakmak, Tugba Kevser Ustunbas/0000-0001-8057-3463; Bozer, Busra/0000-0002-7280-4417en_US
dc.descriptionWOS: 000393798500034en_US
dc.descriptionPubMed: 27613512en_US
dc.description.abstractOxidative stress may play an important role in the pathogenesis of psoriasis. Glutathione S-transferases (GSTs) make up a group of antioxidant enzymes. Cytochrome p450 (CYP) enzymes can influence oxidation and reduction reactions. We investigated the potential effects of GST and CYP enzymes in the pathogenesis of psoriasis. The study included 32 psoriasis patients and 22 healthy subjects. Psoriasis patients were administered 20 sessions of narrowband ultraviolet B phototherapy. Expressions of GST and CYP enzymes were assessed by immunohistochemical staining. Expression levels of GSTK1, GSTM1, and GSTT1 were significantly higher in psoriasis than in control tissues (P = 0.022, P = 0.001, and P = 0.006, respectively). Pre- and post-treatment expression was similar. Expression of CYP1A1 and CYP2E1 was significantly higher in pre- (P = 0.003 and P = 0.001, respectively) and post-treatment (P = 0.003 and P = 0.001, respectively) psoriatic tissues than in control tissues. No significant differences in CYP1B1 levels between the study and control groups were detected before treatment (P > 0.05). However, CYP1B1 levels were higher in post-treatment psoriatic tissue than in control tissue (P = 0.045). The significant increases in expression of GSTK1, GSTM1, and GSTT1 in psoriasis may reflect the increased activation of GST in response to excessive free radical formation from activated neutrophils or ultraviolet exposure to maintain antioxidant capacity in psoriasis. Furthermore, expressions of CYP1A1 and CYP2E1 represent important enzymatic systems in psoriasis. These findings suggest that psoriasis is an oxidative stress condition, although phototherapy does not affect these enzymatic systems. Further investigation is required.en_US
dc.description.sponsorshipIstanbul Medeniyet University Scientific Research Project [TTU-2013-431]en_US
dc.description.sponsorshipThis study was supported by Istanbul Medeniyet University Scientific Research Project 2013 (TTU-2013-431).en_US
dc.language.isoengen_US
dc.publisherWiley-Blackwellen_US
dc.relation.isversionof10.1111/ijd.13343en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcytochrome p450en_US
dc.subjectglutathione S-transferaseen_US
dc.subjectphototherapyen_US
dc.subjectpsoriasisen_US
dc.subjectdermatopathologyen_US
dc.titleAn investigation of cytochrome p450 (CYP) and glutathione S-transferase (GST) isoenzyme protein expression and related interactions with phototherapy in patients with psoriasis vulgarisen_US
dc.typearticleen_US
dc.contributor.departmentKırıkkale Üniversitesien_US
dc.identifier.volume56en_US
dc.identifier.issue2en_US
dc.identifier.startpage225en_US
dc.identifier.endpage231en_US
dc.relation.journalInternational Journal Of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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