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dc.contributor.authorAlp, Esma
dc.contributor.authorCirak, Tamer
dc.contributor.authorDemirbilek, Murat
dc.contributor.authorTurk, Mustafa
dc.contributor.authorGuven, Eylem
dc.date.accessioned2020-06-25T18:23:28Z
dc.date.available2020-06-25T18:23:28Z
dc.date.issued2017
dc.identifier.citationAlp E., Çırak T., Demirbilek M., Türk M., Güven E. (2017). Targeted delivery of etoposide to osteosarcoma cells using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles. Turkish Journal of Biology, 41(5), 719 - 733.en_US
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.urihttps://doi.org/10.3906/biy-1612-17
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7107
dc.descriptionCIRAK, Tamer/0000-0003-0431-9919; Alp, Esma/0000-0002-6650-0759; GUVEN, EYLEM/0000-0001-9039-1698en_US
dc.descriptionWOS: 000414903800004en_US
dc.description.abstractFolic acid (FA)-functionalized poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles were prepared to enhance the delivery efficiency of the anticancer drug etoposide for the clinical treatment of osteosarcoma. PHBV nanoparticles were synthesized by emulsification/solvent evaporation technique and obtained in the size range of 200-250 nm and zeta potential range of -21 and -27 mV. Encapsulation efficiency and in vitro drug release were studied. The cytotoxic, apoptotic, and necrotic effects of PHBV nanoparticles were also investigated using Saos-2 osteosarcoma cells. The results obtained in this study demonstrate that etoposide-loaded and FA-functionalized PHBV nanoparticles can be successfully used for targeted treatment of osteosarcoma.en_US
dc.description.sponsorshipHacettepe University Research FundHacettepe University [09 01 604 001]en_US
dc.description.sponsorshipThis study was financially supported by Hacettepe University Research Fund (Grant No. 09 01 604 001).en_US
dc.language.isoengen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.isversionof10.3906/biy-1612-17en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPHBV nanoparticleen_US
dc.subjectfolate targetingen_US
dc.subjectetoposideen_US
dc.subjecttargeted drug deliveryen_US
dc.subjectosteosarcomaen_US
dc.titleTargeted delivery of etoposide to osteosarcoma cells using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticlesen_US
dc.typearticleen_US
dc.contributor.departmentKırıkkale Üniversitesien_US
dc.identifier.volume41en_US
dc.identifier.issue5en_US
dc.identifier.startpage719en_US
dc.identifier.endpage733en_US
dc.relation.journalTurkish Journal Of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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