dc.contributor.author | Alp, Esma | |
dc.contributor.author | Cirak, Tamer | |
dc.contributor.author | Demirbilek, Murat | |
dc.contributor.author | Turk, Mustafa | |
dc.contributor.author | Guven, Eylem | |
dc.date.accessioned | 2020-06-25T18:23:28Z | |
dc.date.available | 2020-06-25T18:23:28Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Alp E., Çırak T., Demirbilek M., Türk M., Güven E. (2017). Targeted delivery of etoposide to osteosarcoma cells using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles. Turkish Journal of Biology, 41(5), 719 - 733. | en_US |
dc.identifier.issn | 1300-0152 | |
dc.identifier.issn | 1303-6092 | |
dc.identifier.uri | https://doi.org/10.3906/biy-1612-17 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/7107 | |
dc.description | CIRAK, Tamer/0000-0003-0431-9919; Alp, Esma/0000-0002-6650-0759; GUVEN, EYLEM/0000-0001-9039-1698 | en_US |
dc.description | WOS: 000414903800004 | en_US |
dc.description.abstract | Folic acid (FA)-functionalized poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles were prepared to enhance the delivery efficiency of the anticancer drug etoposide for the clinical treatment of osteosarcoma. PHBV nanoparticles were synthesized by emulsification/solvent evaporation technique and obtained in the size range of 200-250 nm and zeta potential range of -21 and -27 mV. Encapsulation efficiency and in vitro drug release were studied. The cytotoxic, apoptotic, and necrotic effects of PHBV nanoparticles were also investigated using Saos-2 osteosarcoma cells. The results obtained in this study demonstrate that etoposide-loaded and FA-functionalized PHBV nanoparticles can be successfully used for targeted treatment of osteosarcoma. | en_US |
dc.description.sponsorship | Hacettepe University Research FundHacettepe University [09 01 604 001] | en_US |
dc.description.sponsorship | This study was financially supported by Hacettepe University Research Fund (Grant No. 09 01 604 001). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Tubitak Scientific & Technical Research Council Turkey | en_US |
dc.relation.isversionof | 10.3906/biy-1612-17 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | PHBV nanoparticle | en_US |
dc.subject | folate targeting | en_US |
dc.subject | etoposide | en_US |
dc.subject | targeted drug delivery | en_US |
dc.subject | osteosarcoma | en_US |
dc.title | Targeted delivery of etoposide to osteosarcoma cells using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles | en_US |
dc.type | article | en_US |
dc.contributor.department | Kırıkkale Üniversitesi | en_US |
dc.identifier.volume | 41 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 719 | en_US |
dc.identifier.endpage | 733 | en_US |
dc.relation.journal | Turkish Journal Of Biology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |