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Öğe Synthesis and biological activity of ferrocenyl furoyl derivatives(Taylor & Francis Inc, 2017) Tombul, Mustafa; Bulut, Adnan; Turk, Mustafa; Ucar, Busra; Isilar, OzerDue to the fact that ferrocene and furan derivatives have long been known to be one of the most biologically active compounds, preparation of their new derivatives might serve a very important purpose. Herein, five furoyl ferrocenes were synthesized via EAS reaction utilizing AlCl3-EtAlCl2 Lewis acids. The compounds 1-5 were obtained in moderate yields and characterized by IR, H-1-NMR, C-13-NMR, and mass spectrometry. Although toxicity increases with concentration, at 100 mu g/mL concentration, the protection of cell viability was observed to be 70% level. At 50 mg/mL concentration, apoptosis in cancer cells observed was 63 +/- 4% leading to high apoptosis ratio for the compound 3. For the compounds (1-5), the necrotic effects were found to be between 21% and 39% at 50 mu g/mL concentration.
