Arslan, HakanAhmed, Hany Mohamed AlySahin, YavuzYildiz, Ezgi DoganayGundogdu, Eyup CandasGuven, YahyaKhalilov, Ruslan2020-06-252020-06-252019closedAccess0099-23991878-3554https://doi.org/10.1016/j.joen.2019.04.005https://hdl.handle.net/20.500.12587/7749Introduction: This preliminary study compared clinical and radiographic outcomes of regenerative endodontic procedures (REPs) with that of conventional root canal treatment (CRCT) in necrotic mature teeth with periapical radiolucencies. Methods: Fifty-six mature necrotic teeth with large periapical radiolucencies were distributed into 2 groups: group 1, REPs and group 2, CRCT (n = 28/group). Clinical and radiographic follow-up assessments were undertaken up to 12 months. Statistical analysis was performed using the independent samples t test and the chi-square test, and the level of significance was set at P = .05. Results: With a follow-up rate of about 73.4% of the total patients for 12 months, favorable clinical and radiographic outcomes were found in 92.3% and 80% in REPs and CRCT groups, respectively, and the difference was not statistically significant (P > .05). Half of the teeth treated with REPs responded to the electric pulp test. Conclusions: Regenerative endodontic procedures have the potential to be used as a treatment option for mature teeth with large periapical radiolucencies.eninfo:eu-repo/semantics/closedAccessApical periodontitismature toothnecrotic toothpulp regenerationpulp revascularizationpulp revitalizationregenerative endodonticsregenerative endodontic procedureArticle45786387210.1016/j.joen.2019.04.0052-s2.0-8506624596931155298Q1WOS:000475410700006Q1