Dursun, ErdemDerhem, BakiCobanoglu, SevalOgurel, Tevfik2025-01-212025-01-2120240721-832X1435-702Xhttps://doi.org/10.1007/s00417-024-06562-2https://hdl.handle.net/20.500.12587/24980Background We aimed to investigate the effect of retinal vein occlusion (RVO) on the posterior segment structures of the eye and its changes with intravitreal anti-Vascular Endothelial Growth Factor (VEGF) treatment. Methods This prospective longitudinal study included 29 eyes of 29 patients with RVO (17 males and 12 females) followed for 6 months. The best corrected visual acuity (BCVA), macula, choroid ticknesses and choroidal vascularity index (CVI) obtained by spectral-domain optical coherence tomography were recorded at baseline and the first, third, and sixth months after the first injection. Results were compared with fellow eyes (non-affected eyes) and age- and sex-matched controls. Results BCVA increased significantly in the 6th month, more in the first month of injection (p < 0.05 for each). Central macular tickness, subfoveal choroid tickness, stromal and total area of choroid decreased significantly after injection (p < 0.05 for each). CVI values increased significantly, especially in the 1st month after injection (p < 0.05 for each). In eyes with Branch RVO, there was a significant decrease in the macular thickness of the occlusive areas with treatment, while there was no statistically significant change in the non-occlusive macular thickness. Conclusion Observation of changes in choroidal structure may be useful to assess the activity of RVO and predict the efficacy of anti-VEGF therapy.eninfo:eu-repo/semantics/openAccessRetinal vein occlusion; Choroid thickness; Central macular thickness; Vascular endothelial growth factor; Choroid vascularity indexArticle262123837384510.1007/s00417-024-06562-22-s2.0-8519928625539037469Q1WOS:001274317000002N/A