Aydın, Halil MuratKorkusuz, PetekVargel, İbrahimKılıç, EmineGüzel, ElifÇavuşoğlu, TarıkPişkin, Erhan2020-06-252020-06-252011Aydin HM, Korkusuz P, Vargel İ, et al. A 6-month in vivo study of polymer/mesenchymal stem cell constructs for cranial defects. Journal of Bioactive and Compatible Polymers. 2011;26(2):207-221.0883-91151530-8030https://doi.org/10.1177/0883911511399411https://hdl.handle.net/20.500.12587/5047Meydanli, E. Elif Guzel/0000-0001-9072-3322; KILIC, Emine/0000-0003-2984-7638; KORKUSUZ, PETEK/0000-0002-7553-3915Two biodegradable polymers, poly(L-lactide) and poly(epsilon-caprolactone) were blended (50/50) and used to produce polymeric scaffolds by the dual porogen approach using a salt leaching technique to create pores within the matrix, while supercritical-CO2 treatment was used to enhance the interconnectivity and to remove impurities from synthesis steps. The scaffolds were highly porous (porosity >90%) with interconnected pore morphologies. These biodegradable scaffolds were evaluated in Sprague Dawley rats for osteoconductive properties over a 6-month period. Bone specimens were analyzed after 1, 3, and 6 months, for bone healing and tissue response. The cortical bone remodeling by controlled osteoblastic and osteoclastic activities as well as the bone marrow elements recovery were semi-quantitatively examined for each group. Excellent integration and biocompatibility behavior was observed in all groups. No adverse tissue responses were observed.eninfo:eu-repo/semantics/openAccessbiodegradable scaffoldsbone marrowbone tissue engineeringin vivo studyosteoclastic activitypolymeric blendssalt leachingsupercritical CO2Article26220722110.1177/08839115113994112-s2.0-79956092612Q3WOS:000288783600008Q1