Guzel, MuratDogru, Mehmet TolgaSimsek, VedatDemir, VahitAlp, CaglarKandemir, HuseyinKisa, Ucler2020-06-252020-06-252019Guzel M, Dogru MT, Simsek V, Demir V, Alp C, Kandemir H, Yildirim N, Kisa U. Influence of circadian blood pressure alterations on serum SCUBE-1 and soluble CD40 ligand levels in patients with essential hypertension. Am J Cardiovasc Dis. 2019 Aug 15;9(4):42-48.2160-200Xhttps://hdl.handle.net/20.500.12587/7924KISA, Ucler/0000-0002-8131-6810Background: Dipper and non-dipper hypertension are different clinical forms of essential hypertension. In this study, the effect of circadian blood pressure changes on serum SCUBE-1 and soluble CD40 ligand (sCD40L) levels was investigated in patients with hypertension. Methods: A total of 100 participants aged 23-89 years were included in the study. Patients with essential hypertension were followed up by ambulatory blood pressure measurement. Results: Serum SCUBE1 levels were significantly higher in the non-dipper group than in the normal group (P < 0.001). Dipper and non-dipper patients had significantly higher serum sCD40L levels when compared to the normal group (P = 0.048 and P = 0.035, respectively). We also found a positive correlation between SCUBE1, sCD40L levels and 24-hour mean systolic blood pressure levels (r: 0.232, p: 0.034 and r: 0.241, p: 0.027, respectively). Conclusion: Serum SCUBE1 and sCD40L levels were higher in hypertensive patients than normal participants. Serum SCUBE1 levels were higher in patients with non-dipper compared to other participants.eninfo:eu-repo/semantics/openAccessSCUBE1 protein humansCD40L proteinhypertensionblood pressure monitoringArticle94424831516762WOS:000485155700003N/A