Guncum, EnesGeyik, GulcanIsiklan, Nuran2025-01-212025-01-2120240378-51731873-3476https://doi.org/10.1016/j.ijpharm.2024.124287https://hdl.handle.net/20.500.12587/25072Multifunctional nanoplatforms developed from natural polymers and graphene oxide (GO) with enhanced biological/physicochemical features have recently attracted attention in the biomedical field. Herein, a new multifunctional near -infrared (NIR) light-, pH- and magnetic field -sensitive hybrid nanoplatform (mGO@AL-gPHPM@ICG/EP) is developed by combining iron oxide decorated graphene oxide nanosheets (mGO) and poly(2hydroxypropylmethacrylamide) grafted alginate (AL-g-PHPM) copolymer loaded with indocyanine green (ICG) and etoposide (EP) for chemo/phototherapy. The functional groups, specific crystal structure, size, morphology, and thermal stability of the nanoplatform were fully characterized by XRD, UV, FTIR, AFM/TEM/FE-SEM, VSM, DSC/TG, and BET analyses. In this platform, the mGO and ICG, as phototherapeutic agents, demonstrate excellent thermal effects and singlet oxygen production under NIR-light (808 nm) irradiation. The XRD and DSC analysis confirmed the amorphous state of the ICG/EP in the nanoparticles. In vitro photothermal tests proved that the mGO@AL-g-PHPM@ICG/EP nanoparticles had outstanding light stability and photothermal conversion ability. The in vitro release profiles presented NIR light-, pH- and magnetic field -controlled EP/ICG release behaviors. In vitro experiments demonstrated the excellent antitumor activity of the mGO@AL-g-PHPM@ICG/EP against H1299 tumor cells under NIR laser. Benefiting from its low-cost, facile preparation, and good dualmodal therapy, the mGO@AL-g-PHPM@ICG/EP nanoplatform holds great promise in multi -stimuli -sensitive drug delivery and chemo/phototherapy.eninfo:eu-repo/semantics/closedAccessAlginate copolymer; Multi -stimuli -sensitive nanoparticle; Magnetic graphene oxide; Etoposide; Indocyanine green; PhototherapyArticle65910.1016/j.ijpharm.2024.1242872-s2.0-8519491773538815638Q1WOS:001249755400001N/A