Zengin, MehmetBenek, Suat2021-01-142021-01-142020Bu makale açık erişimli değildir.1219-49561532-2807https://doi.org/10.1007/s12253-020-00877-1https://hdl.handle.net/20.500.12587/12632Benek, Suat/0000-0003-0774-7695The importance of tumour microenvironment in tumour behaviour has now become clearer. This study aimed to determine the prognostic effect of the proportion of tumour-stroma (PTS) in metastatic lymph nodes of advanced-stage colon cancers (CCs). We investigated PTS in positive lymph nodes of stage III-IV CC patients who underwent surgical treatment between 2004 and 2014. We used a standard approach in methodology. PTS was significantly associated with prognostic factors in the metastatic lymph nodes (perineural invasion [p = 0.031], lymphatic invasion [p = 0.032], invasive margin [p = 0.043], advanced pT [p = 0.020], and margin involvement [p = 0.034]). In addition, the correlations between PTS estimates (R = 0.704 to 0.617,p < 0.001), the reproducibility of the research (Kappa appa = 0.72-0.68) and the usefulness of the cut-off value (ROC: 50.33%; AUC = 0.752 [0.667-0.857]) were successful. In univariate analysis, 5-year survival was poor for RFS (p < 0.001), OS (p = 0.001) and LR (p = 0.013) in high PTS patients. Multivariate analysis confirmed that high PTS was an independent worse parameter for RFS (HR = 1.32, 95% CI: 1.17-2.55,p = 0.001) and OS (HR = 1.37, 95% CI: 1.25-1 - 2.56,p = 0.009). In this study, we showed that high PTS in metastatic lymph nodes was a successful prognostic marker for advanced-stage CCs. Also, the standard approach we used for the methodology was successful.eninfo:eu-repo/semantics/closedAccessColon cancersProportion of tumour-stromaPathologyPrognostic markersStage III-IVArticle2642755276410.1007/s12253-020-00877-12-s2.0-8508839704132696416Q1WOS:000551024800001Q2