McCusker, KevinChalafant, AnthonyFoe, Gordon deGünaydın, SerdarVijay, Venkataramana2020-06-252020-06-252006closedAccess0267-65911477-111Xhttps://doi.org/10.1191/0267659106pf863oahttps://hdl.handle.net/20.500.12587/3665Background: The couplings between cerebral oxygenation (rSO(2)), on-pump hematocrit and circuit prime are explored in this study. Methods: Thirty-eight consecutive patients undergoing coronary revascularization with cardiopulmonary bypass (CPB) were matched on preoperative hematocrit < 40% and > 40% (n = 16). Similarly, six blood prime patients were matched with six crystalloid prime patients. Hematocrit and rSO(2) levels were then compared on CPB. Results: The preoperative hematocrit > 40% group retained higher levels on pump run (p < 0.01) and significantly higher rSO(2) prior to CPB (64.8 +/- 9.6 versus 73.2 +/- 7.3), and on and off CPB (61.1 +/- 8.8 versus 67.4 +/- 6.4). Blood priming increased absolute rSO(2) (2.3 +/- 6.3 versus -10.9 +/- 5.9) and % rSO(2) (4.7 +/- 11.8 versus -14.2 +/- 7.4%) in the low hematocrit group. Conclusion: Blood primes are instrumental in high-risk and low preoperative hematocrit patients in preventing cerebral oxygen desaturation during initiation and maintenance of CPB.eninfo:eu-repo/semantics/closedAccessArticle21314915510.1191/0267659106pf863oa2-s2.0-3374531332716817287Q1WOS:000237223000004Q4