Aydın, AliÖkten, SalihErkan, SultanBulut, MerveÖzcan, EvrencanTutar, AhmetEren, Tamer2025-01-212025-01-2120212365-6549https://doi.org/10.1002/slct.202004753https://hdl.handle.net/20.500.12587/23443The present study describes mono substituted indeno[1,2-b]quinolines (3 a–c and 5) have much more antiproliferative potentials than positive controls against A549, HeLa, MCF7 and Hep3B cell lines (IC50 values 1.1–29.6 ?g/mL) and show similar cytotoxicity (14.3 % to 19.8 %) to cells such as controls. Moreover, the mono substituted indeno[1,2-b]quinoline amines (3 a–c and 5) exhibit significant antimicrobial activity with MIC values between 15.62 ?g/mL and 250 ?g/mL. The compounds can also bind to DNA in the groove binding mode with a binding constant range of 1.1×103–1.1×105 M?1. The anticancer and antibacterial properties of compounds were confirmed with the molecular docking simulation for their pharmacokinetic. As a result, the preliminary experimental data and a multi-criteria decision-making methodology (MCDM) indicated that the mono substituted indeno[1,2-b]quinoline amine derivatives, especially 3 a and 5, exhibit effective pharmacological properties. parameters and their interaction with related cells at the molecular level. © 2021 Wiley-VCH GmbHeninfo:eu-repo/semantics/closedAccessAntibacterial agents; Antitumor agents; Biological activity; Indeno[1,2-b]quinoline amine; Molecular docking; Multi criteria decision makingArticle6133286329510.1002/slct.2020047532-s2.0-85107543872Q3