Genc, A. I.Adali, O.Kul, O.Ozkan, A. M. Gencler2020-06-252020-06-252019closedAccess0378-42741879-3169https://hdl.handle.net/20.500.12587/765755th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology - Science Providing Solutions -- SEP 08-11, 2019 -- Helsinki, FINLANDRheumatoid arthritis is an idiopathic auto-immune disease characterized destruction of cartilage and synovial membrane. TNF-alpha, IL-12 and IL-1 are well known inflammatory mediators of “rheumatoid arthritis”. These cytokines activate synoviocytes and chondrocytes and this results in the secretion of matrix metalloproteinase into the synovial fluid. Analgesic and anti-inflammatory drugs are used to suppress the symptoms. However, all these have several side effects. New therapies targeting the underlying immune process have been proposed. Recent research aims to discover long-acting anti-inflammatory drugs with minimal side effects. Sanguisorba minor subsp. Balearica (Smb) is known as a medicinal plant and has been used for treatment of various disorders. The usage of Smb for relieving of inflammation is noteworthy. This study aims to invastigate possible cytokine mediated anti-inflammatory effects of (Smb) on arthritic ratseninfo:eu-repo/semantics/closedAccessConference Object314S180S180WOS:000484771800484Q1