Yildirim, C.Muluk, N. BayarKar, M.Kaya, F.Cingi, C.2025-01-212025-01-2120221128-3602https://doi.org/10.26355/eurrev_202212_30476https://hdl.handle.net/20.500.12587/24983OBJECTIVE: We aimed to create an ideal ointment combination to provide fast wound healing with the highest patient comfort after nasal surgery and nasal flap surgery. MATERIALS AND METHODS: Twenty-one male Wistar rats were included. The flap survival method was used. The rats' healing process was evaluated in all groups. After having the same surgical procedure, the following ointments were applied to flap borders twice a day for seven days in each of the groups. In group 1 (Control, n=7), Dexpanthenol 5% (Dex); in group 2, Dex, Ciprofloxacin 0.5 % (Cip) and Ephedrine hydrochloride 1% (Eph); in group 3, Dex+Cip+Eph and Ketoprofen 2.5% (Ket) was applied. On the seventh postoperative day, the size of the necrosis on the flap was evaluated. RESULTS: Median necrotic areas on skin flaps were 36.00% sq mm in group 1, 23.00% sq mm in group 2, and 5.00% sq mm in group 3. Flap necrosis areas on skin flaps were group 3eninfo:eu-repo/semantics/closedAccessFlap necrosis; rat; Dexpantenol; Ciprofloxacin; Ephedrine hydrochloride; KetoprofenArticle2691410.26355/eurrev_202212_3047636524906WOS:000911202200002Q2