Karaca, Emine EsraUzun, FeyzahanDilekoz, ErginFincan, Gokce Sevim OzturkErcan, SevimKul, OguzOr, Meral2020-06-252020-06-252018closedAccess1556-95271556-9535https://doi.org/10.1080/15569527.2017.1355317https://hdl.handle.net/20.500.12587/7563Uzun, Feyzahan/0000-0002-3050-0714Purpose: To investigate the effect of Bosentan (non-selective endothelin receptor antagonist) and BQ123 (ETA receptor antagonist) on intraocular inflammation in an endotoxin-induced uveitis (EIU) rabbit model.Methods: Uveitis was induced by intravitreal injection of lipopolysaccharide (LPS). The animals were divided into 7 groups and there were six rabbits in each group (saline, saline and ethanol, bosentan, BQ123, lipopolysaccharide (LPS), bosentan and LPS, BQ123 and LPS-injected groups). Bosentan and BQ123 were applied before LPS injection. Aqueous humour was collected at 24th hour post-injections and enucleation was performed for the evaluation of histopathological changes.Results: BQ123 decreased clinical score, cell counts and protein amount more than bosentan and it was significant for cell counts (p=0.018). Bosentan significantly diminished inflammatory reactions more than BQ123 as shown in histopathological specimens (p=0.002).Conclusions: ETA receptor blockage is effective on uveitis treatment by its protective effect on blood aqueous barrier.eninfo:eu-repo/semantics/closedAccessUveitislipopolysaccharidesendothelin receptorsendothelinArticle37213313810.1080/15569527.2017.13553172-s2.0-8503140248928707522Q3WOS:000429276400005Q4