Copper-catalyzed asymmetric conjugate addition of diethylzinc to substituted chalcones using a chiral phosphine ligand

Dogan, OzdemirBulut, AdnanPolat, SavasTecimer, M. Ali2020-06-252020-06-252011closedAccess0957-4166https://doi.org/10.1016/j.tetasy.2011.09.003https://hdl.handle.net/20.500.12587/4941A series of chiral phosphine PFAM and phosphine oxide POFAM ligands were studied for the copper-catalyzed asymmetric diethylzinc addition to enones. One of these ligands, PFAM2, was an efficient catalyst with a variety of enones to give conjugate addition products in up to 96% yield and 92% ee. (C) 2011 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessCopper-catalyzed asymmetric conjugate addition of diethylzinc to substituted chalcones using a chiral phosphine ligandArticle2216-171601160410.1016/j.tetasy.2011.09.0032-s2.0-81155137919N/AWOS:000298220200002Q2