Arslan, M.Sezen, S. C.Turgut, H. C.Kocabiyik, M.Arpaci, H.Comu, F. M.Kavutcu, M.2020-06-252020-06-252016Arslan, M., Sezen, S. C., Turgut, H. C., Kocabiyik, M., Arpaci, H., Comu, F. M., Ozturk, L., & Kavutcu, M. (2016). Vitamin C ameliorates high dose Dexmedetomidine induced liver injury. Bratislavske lekarske listy, 117(1), 36–40.0006-92481336-0345https://doi.org/10.4149/BLL_2016_008https://hdl.handle.net/20.500.12587/6768Arslan, Mustafa/0000-0003-4882-5063BACKGROUND: We investigated whether vitamin C has protective effects on rat liver tissue treated with different dexmedetomidine doses. MATERIAL AND METHODS: Thirty five wistar albino rats were randomly divided into 5 groups (Control (0.9 % NaCI intraperitoneally (ip), Dexmedetomidine 5 mu g.kg(-1) (ip), Dexmedetomidine 5 mu g.kg(-1) ip plus Vitamin C (100 mng.kg(-1)), Dexmedetomidine 10 mu g.kg(-1) ip and Dexmedetomidine 10 mu g.kg(-1) ip plus Vitamin C (100 mg.kg-1). Histopathological liver injury, superoxide dismutase (SOD) activity and tissue Malondialdehyde levels were investigated. RESULTS: Hepatocyte degeneration was significantly higher in D10 group than those in other study groups (p < 0.0001, p = 0.002, p < 0.0001, p = 0.005, respectively). Similarly, liver tissue sinusoidal dilatation and hepatocyte necrosis were significantly higher in D10 group than those in other groups (p < 0.0001, p < 0.0001, p = 0.002, p < 0.0001 and p < 0.0001, p = 0.046, p < 0.0001 and p = 0.002, respectively). Tissue MDA levels in D10 group were significantly higher than those in control, D5+Vit C and D10+Vit C groups (p = 0.028, p = 0.004, p = 0.031, respectively). SOD enzyme activity in D10 group was significantly lower than in control, D5+Vit C and D10+Vit C groups (p < 0.0001, p = 0.023 and p = 0.031, respectively). CONCLUSION: High dose dexmedetomidine can induce hepatic injury and oxidative stress in rats while pretreatment with vitamin C may be effective in protecting liver tissue against this newly recognized undesirable dexmedetomidine effect (Tab. 2, Fig. 5, Ref. 30). Text in PDF www.elis.sk.eninfo:eu-repo/semantics/openAccessDexmedetomidinevitamin Cliver histopathologyMDASODratArticle1171364010.4149/BLL_2016_0082-s2.0-8501486367026810168Q2WOS:000370112600008Q3