Demirer, SerhatKara, M. IsaErciyas, KamileOzdemir, HakanOzer, HaticeAy, Sinan2020-06-252020-06-252012closedAccess0003-99691879-1506https://doi.org/10.1016/j.archoralbio.2011.07.012https://hdl.handle.net/20.500.12587/5386erciyas, kamile/0000-0001-9940-0423Objective: The goal of the present study was to evaluate the histopathologic and morphometric effects of systemic boric acid in a rat periodontitis model. Design: Twenty-four Wistar rats were divided into three groups of eight animals each: non-ligated (NL), ligature only (LO), and ligature and treated with boric acid (BA) (3 mg/kg per day for 11 days). A 4/0 silk suture was placed in a subgingival position around the mandibular first molars; after 11 days the rats were sacrificed, and changes in alveolar bone levels were measured clinically and tissues were histopathologically examined to assess the differences amongst the study groups. Results: The ratio of presence of inflammatory cell infiltration (ICI) and osteoclast number in the LO group was significantly higher than that of the NL and BA groups (p < 0.05). The ratio of presence of osteoblastic activity in the LO group was significantly lower than that of the NL and BA groups (p < 0.05). Alveolar bone loss was also significantly higher in the LO group compared to the BA and NL groups (p < 005). Conclusions: This study has demonstrated that systemic administration of boric acid reduced periodontal inflammation and alveolar bone loss in periodontal disease in rats. (C) 2011 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessExperimental periodontitisRatOxidative stressAntioxidantArticle571606510.1016/j.archoralbio.2011.07.0122-s2.0-8415516766521871607Q1WOS:000300122800009Q2