Kandemir, SüheylaPamuk, A.ErimÖzel, GökçeGençay, IşınKılıç, Rahmi2025-01-212025-01-2120230003-4894https://doi.org/10.1177/00034894221089162https://hdl.handle.net/20.500.12587/23635Aims: This study aimed to compare the efficacy of gabapentin, dexamethasone, and gabapentin + dexamethasone for pain control after septoplasty. Materials and Methods: This prospective randomized trial included 120 patients that underwent septoplasty and were randomly divided into 4 groups: group G (preoperative gabapentin 600 mg p.o.); group D (intraoperative dexamethasone 8 mg i.v.); group GD (preoperative gabapentin 600 mg p.o. + intraoperative dexamethasone 8 mg i.v.); group C (placebo control). Results: The median VAS score was significantly lower in groups G and GD at 1, 2, 4, 6, 12, and 24 hours postsurgery than in group C (P <.008 for all). The median VAS score was significantly lower in group D than in group C at 1, 2, and 4 hours postsurgery (P <.008 for all). There weren’t any significant differences in the VAS score between groups D, G, and GD at any time point. Groups G, D, and GD had a significantly lower frequency of rescue analgesic use than group C; however, there were no differences between groups G, GD, and C (P <.001 and P =.108, respectively). Conclusion: Gabapentin, dexamethasone, and gabapentin + dexamethasone are equally more effective analgesics during the first 4 hours postsurgery than placebo. The addition of dexamethasone to gabapentin does not provide extra analgesia. Both gabapentin and gabapentin + dexamethasone have a more prolonged analgesic effect than dexamethasone alone. © The Author(s) 2022.eninfo:eu-repo/semantics/closedAccessanalgesia; dexamethasone; gabapentin; postoperative pain; septoplastyArticle132330430910.1177/000348942210891622-s2.0-8512972753135450447Q2