Erkek, EmelBaşar, HalilBozdoğan, ÖnderEmeksiz, M. Can2020-06-252020-06-252009closedAccess0307-6938https://doi.org/10.1111/j.1365-2230.2008.02938.xhttps://hdl.handle.net/20.500.12587/4468emeksiz, can/0000-0002-0933-4619Human papillomavirus (HPV) is the most common sexually transmitted disorder in young, sexually active populations in the USA and Europe. Giant condyloma acuminatum (GCA) is a unique variant of condyloma acuminata, characterized by local aggressive behaviour despite benign histology. It carries a substantial risk of squamous cell carcinoma. Various treatments have been used, but response is often poor and recurrence rates high. We present a case of GCA successfully treated with a combination of surgical excision, oral acitretin and topical imiquimod. The diagnosis was based on histological examination, immunohistochemical analysis and in situ hybridization for HPV 6 and 11. We recommend a trial of oral retinoid and topical imiquimod in selected cases of GCA.eninfo:eu-repo/semantics/closedAccessArticle34336636810.1111/j.1365-2230.2008.02938.x2-s2.0-6244909521219175780Q2WOS:000264163000021Q3