Ozcelik, Azime BernaUtku, SemraGumus, FatmaKeskin, Ayten CelebiAcik, LeylaYilmaz, SukranOzgungor, Adeviye2020-06-252020-06-252012closedAccess1475-6366https://doi.org/10.3109/14756366.2011.594046https://hdl.handle.net/20.500.12587/5265UTKU, Semra/0000-0003-3181-9134In the present study, four Pt(II) complexes with 2-ethyl (1)/or benzyl (2)/or p-chlorobenzyl (3)/or 2-phenoxymethyl (4) benzimidazole carrier ligands were evaluated for their in vitro cytotoxic activities against the human HeLa cervix, oestrogen receptor-positive MCF-7 breast, and oestrogen receptor-negative MDA-MB 231 breast cancer cell lines. The plasmid DNA interactions and inhibition of the BamHI restriction enzyme activities of the complexes were also studied. Complex 3 was found to be more active than carboplatin for all examined cell lines and comparable with cisplatin, except for the HeLa cell line.eninfo:eu-repo/semantics/closedAccessBenzimidazoleplatinum(II) complexescytotoxic activityDNA bindinggel electrophoresisArticle27341341810.3109/14756366.2011.5940462-s2.0-8486036685822299582Q1WOS:000303330100012Q4