Çiftçi, Faika CeylanTuğcu, A UlaşÇiftçi, Özgür2021-01-142021-01-142019Çiftçi F. C., Tuğcu A. U., Çiftçi Ö. (2019). Sub-clinic atherosclerosis in patients with postprandia reactive hypoglycemia. Annals of Medical Research, 26(12), 2941 - 2947.2636-76882636-7688https://doi.org/10.5455/annalsmedres.2019.10.609https://app.trdizin.gov.tr/makale/TXpVNU1qRXlNZz09https://hdl.handle.net/20.500.12587/13137Aim: Hypoglycemia is associated with excessive cardiovascular mortality because of the pro-inflammatory and pro-atherothrombotic pathway stimulation. Hypoglycemia is known to affect the development of sub-clinic atherosclerosis. This study aims to determine the development of sub-clinic atherosclerosis in patients with postprandial reactive hypoglycemia by investigating thickness of carotid intima media and epicardial fat, and high-sensitivity C-reactive protein values and their relationships with each other. Material and Methods: 51 patients in total were included in the project, including 28 patients (37.50±10.82 years) who had hypoglycemia symptoms and who had hypoglycemia during prolonged oral glucose tolerance test and 23 healthy adult volunteers (35.01±10.92 years) as a control group. Subjects underwent echocardiographic examination including EFT and IMT measurement using transthoracic echocardiography. Results: Postprandial Reactive Hypoglycemia group were marked with higher high-sensitivity C-reactive protein levels (1.67±0.67 vs. 1.20±0.52; p= 0.007), carotid intima media thickness (0.65±0.10 vs. 0.50±0.10; p<0.001) and epicardial fat thickness (0.57±0.07 vs. 0.48±0.08; p= 0.001) values as compared to the control group. Conclusion: Patients with postprandial reactive hypoglycemia had impaired epicardial fat thickness and increased thickness of carotid intima media, and carotid intima media thickness linked with significantly with high-sensitivity C-reactive protein. These observations support the importance of chronic inflammation mechanism for the development of sub-clinic atherosclerotic disease in postprandial reactive hypoglycemia.eninfo:eu-repo/semantics/openAccessArticle26122941294710.5455/annalsmedres.2019.10.609359212