Tombul, MustafaBulut, AdnanTurk, MustafaUcar, BusraIsilar, Ozer2020-06-252020-06-252017closedAccess2470-15562470-1564https://doi.org/10.1080/15533174.2016.1218510https://hdl.handle.net/20.500.12587/7208Due to the fact that ferrocene and furan derivatives have long been known to be one of the most biologically active compounds, preparation of their new derivatives might serve a very important purpose. Herein, five furoyl ferrocenes were synthesized via EAS reaction utilizing AlCl3-EtAlCl2 Lewis acids. The compounds 1-5 were obtained in moderate yields and characterized by IR, H-1-NMR, C-13-NMR, and mass spectrometry. Although toxicity increases with concentration, at 100 mu g/mL concentration, the protection of cell viability was observed to be 70% level. At 50 mg/mL concentration, apoptosis in cancer cells observed was 63 +/- 4% leading to high apoptosis ratio for the compound 3. For the compounds (1-5), the necrotic effects were found to be between 21% and 39% at 50 mu g/mL concentration.eninfo:eu-repo/semantics/closedAccessFerrocenefuranbiological activitycytotoxicitysynthesisArticle47686586910.1080/15533174.2016.12185102-s2.0-85026832966Q2WOS:000396521300012Q4