Ozkan, YesimSukuroglu, Murat KadirTulmac, MuratKisa, UclerSimsek, Bolkan2020-06-252020-06-252014closedAccess1433-6510https://doi.org/10.7754/Clin.Lab.2013.121204https://hdl.handle.net/20.500.12587/5907KISA, Ucler/0000-0002-8131-6810; OZKAN, YESIM/0000-0002-1669-4962Background: Inflammation and immune activation have a crucial role in the pathogenesis of cardiovascular diseases. Indolamine 2,3-dioxygenase, a tryptophan catabolising enzyme, is up-regulated with various inflammatory stimuli. The aim of this study was to evaluate the relationship of tryptophan degradation with immune and inflammatory markers in coronary artery disease. Methods: 57 subjects undergoing coronary angiography were recruited. 18 subjects with normal coronary arteries according to Gensini scoring were selected as a control group and the rest of subjects were included in patient group. Serum tryptophan and kynurenine levels were determined with HPLC-UV method, and kynurenine/tryptophan ratio was evaluated as IDO activity. Serum neopterin and myeloperoxidase activity were measured by ELISA method. Results: While the kynurenine/tryptophan ratio and neopterin levels were similar in both groups, the patient group had higher myeloperoxidase and hs-CRP levels than controls (p = 0.02, p = 0.002, respectively). The kynurenine/tryptophan ratio was correlated with neopterin in both groups (r = 0.389, p = 0.025; r = 0.683, p = 0.002, respectively) and with hs-CRP in patients (r = 0.637, p = 0.001). Also, neopterin levels were correlated with hs-CRP in patients (r = 0.755, p = 0.0001). Conclusions: Our results are in line with a role of inflammation in coronary artery disease. The study provides evidence that IDO activity is related with immune and inflammatory states. Also, the study was performed in a limited hospital-based population. Further studies are warranted in the larger groups.eninfo:eu-repo/semantics/closedAccessatherosclerosisindolamine 2,3-dioxygenasekynurenineneopterintryptophanArticle60339139610.7754/Clin.Lab.2013.1212042-s2.0-8489647488624697114Q3WOS:000342857300006Q3