Dag, ErselOrnek, NurgulOrnek, KemalErbahceci-Timur, Inci Elif2020-06-252020-06-252014closedAccess1070-80221536-5166https://doi.org/10.1097/WNO.0000000000000068https://hdl.handle.net/20.500.12587/5803Ornek, Nurgul/0000-0003-3068-1831Background: To investigate the optical coherence tomography (OCT) and visual field findings in Friedreich ataxia (FRDA). Methods: Ten eyes of 10 patients with genetically confirmed FRDA were included in this study. Twenty-two eyes of 22 age- and sex-matched volunteers served as controls. All eyes were examined with spectral domain OCT (Retinascan Advanced RS-3000; NIDEK) and Humphrey Field Analyzer (HFA II 750; Zeiss-Humphrey Systems). Results: OCT measurements of the average peripapillary retinal nerve fiber layer (RNFL) thickness, average peripapillary retinal thickness (RT), and foveal RT showed a statistically significant reduction in patients with FRDA (P, 0.0001). There was no statistically significant difference in choroidal thickness. OCT measurements of horizontal cup-to-disc (C/D) ratio, vertical C/D ratio, and average cup area were significantly increased in patients with FRDA. Visual acuity was significantly correlated with age at onset (P = 0.021) and average RNFL value (P = 0.045). There was a significant correlation between foveal thickness and disease duration (P = 0.014). Mean RNFL thickness was significantly correlated with the severity of neurological involvement (P = 0.039). Visual field testing (VFT) revealed a generalized reduction of sensitivity in the patients. Conclusion: Patients with FRDA may have a measurable degree of retinal thinning as determined by OCT and a generalized reduction of sensitivity in VFT. Combining structural and functional findings may be used in the follow-up of patients with FRDA. (C) 2013 by North American Neuro-Ophthalmology Societyeninfo:eu-repo/semantics/closedAccessArticle34211812110.1097/WNO.00000000000000682-s2.0-8490080164524275983Q2WOS:000337246200003Q2