Çakmak, OsmanÖkten, SalihAlimli, DilekSaddiqa, AishaErsanlı, Cem Cüneyt2020-06-252020-06-252018Çakmak, O., Okten, S., Alimli, D., Saddiqa, A., & Ersanli, C. C., (2018). Activation of 6-bromoquinoline by nitration: synthesis of morpholinyl and piperazinyl quinolines. ARKIVOC , vol.2018, 362-374.1551-70041551-7012https://doi.org/10.24820/ark.5550190.p010.374https://hdl.handle.net/20.500.12587/7523Alimli, Dilek/0000-0003-4564-9447; Hokelek, Tuncer/0000-0002-8602-4382; Okten, Salih/0000-0001-9656-1803Quinoline forms the key skeletal component of a number of important natural products and pharmacologically-active compounds. Despite a tremendous amount of research pertaining to the derivatization of quinoline, very few general synthetic routes are described in the literature starting from quinoline or tetrahydroquinoline. A simple and convenient method for the polyfunctionalization of quinolines via nitration of bromoquinolines has been developed. This method represents a new synthetic approach to convert brominated nitroquinoline derivatives into useful cyclic amines via nucleophilic-substitution (SNAr) reaction. [GRAPHICS] .eninfo:eu-repo/semantics/openAccessNitrationN-oxidation6-bromoquinolineaminoquinolinequinoline N-oxidesmorpholinyl and piperazinyl quinolinesArticle36237410.24820/ark.5550190.p010.3742-s2.0-85049176940Q4WOS:000438799100030Q3