The effects of low and high doses of sugammadex on kidney tissue in streptozotocin-induced diabetic rats

Kip, G.Turgut, H. C.Alkan, M.Aydin, M. E.Erbatur, M. E.Kiraz, H. A.Unal, Y.2020-06-252020-06-252015Kip, G., Turgut, H. C., Alkan, M., Aydin, M. E., Erbatur, M. E., Kiraz, H. A., Kartal, S., Boyunaga, H., Comu, F. M., Erdem, O., Arslan, M., & Unal, Y. (2015). The effects of low and high doses of sugammadex on kidney tissue in streptozotocin-induced diabetic rats. Bratislavske lekarske listy, 116(12), 746–750.0006-92481336-0345https://doi.org/10.4149/BLL_2015_146https://hdl.handle.net/20.500.12587/6275Arslan, Mustafa/0000-0003-4882-5063; Erdem, Ayhan/0000-0001-7761-1078; AYDIN, Muhammed Enes/0000-0001-8491-6566BACKGROUND: Sugammadex is primarily excreted via renal route. We investigated effects of low and high doses of sugammadex (16 mg/kg versus 96 mg/kg) on renal tissue samples of streptozotocin-induced diabetic rats. MATERIAL AND METHODS: Twenty-four Wistar albino rats were divided into 4 groups. Group C (control - 0.9 % NaCl), Group DC (diabetes control; 55 mg/kg streptozotocin, IP, only), Group DR-16S (diabetes-rocuronium - 16 mg sugamnnadex, IV.) and Group DR-96S (diabetes- rocuronium - 96 mg sugammadex, IV). Renal tissue histopathological evaluation and antioxidant status (measurements of MDA levels and NO activities) were studied. RESULTS: Significantly higher levels of all inflammation parameters (inflammation, degeneration/necrosis, tubular dilatation, tubular cell degeneration, dilatation in Bowman's space, tubular hyaline casts, and lymphocyte infiltration) were found in the 96 mg/kg sugammadex group. Higher MDA tissue levels and lower NO activity were found in the 96 mg/kg sugammadex group. DISCUSSION: We can conclude that high-dose (96 mg/kg) sugammadex administration resulted in significant renal tissue damage in diabetic rats. As a consequence, low doses of sugamnnadex have to be preferred in diabetic patients (Tab. 2, Fig. 4, Ref. 26). Text in PDF www.elis.sk.eninfo:eu-repo/semantics/openAccesssugammadexstreptozotocindiabetesrenal damageThe effects of low and high doses of sugammadex on kidney tissue in streptozotocin-induced diabetic ratsArticle1161274675010.4149/BLL_2015_1462-s2.0-8497336915926924146Q2WOS:000367280800011Q4