Kucuk, AysegulComu, Faruk MetinGuney, SevinErkent, Fatmanur DurukIsik, BerrinOzturk, LeventArslan, Mustafa2025-01-212025-01-2120222147-2092https://doi.org/10.12996/gmj.2022.06https://hdl.handle.net/20.500.12587/237121st International Hippocrates Congress of Hippocrat Medicine and Health Sciences -- MAR 01-03, 2019 -- Ankara, TURKEYObjectives: The aim of this study was to investigate the association between Alzheimer's disease and erythrocyte deformability and to assess whether recurrent sevoflurane anesthesia influenced this association. Methods: A total of 24 Wistar albino rats were divided into four groups: Control, sevoflurane, Alzheimer, and Alzheimer + sevoflurane. The experimental Alzheimer model was prepared by intracerebroventricular injection of streptozotocin at a dose of 3 mg/kg (10 mu l) to the Alzheimer and Alzheimer + sevoflurane groups. Sevoflurane (2.3%) was administered to the sevoflurane and Alzheimer + sevoflurane groups 4 weeks after the surgery for 3 days and lasting for 2 hours per day. Blood samples were then collected for deformability measurements. Results: The deformability index was significantly increased in Alzheimer-induced rats, but the results for the Alzheimer and Alzheimer + sevoflurane groups were similar. The erythrocyte deformability index was significantly increased in the Alzheimer and Alzheimer + sevoflurane groups (p=0.004 p=0.001 respectively). However, there was no difference in deformability in the sevoflurane group (p= 0.496) Conclusion: Erythrocyte deformability was increased in the Alzheimer-induced rats; however recurrent sevoflurane anesthesia did not affect erythrocyte deformability.eninfo:eu-repo/semantics/openAccessAlzheimer disease; erythrocyte deformability; sevoflurane; rat; animal models experimentalConference Object331252810.12996/gmj.2022.062-s2.0-85122575726Q4WOS:000733303100005N/A