Bayram, MerihBostanci, SuhhaCaglayan, OsmanIlhan, Mustafa N.2020-06-252020-06-252008closedAccess0741-238X1865-8652https://doi.org10.1007/s12325-008-0041-yhttps://hdl.handle.net/20.500.12587/4185Introduction: The aim of our study was to analyse the role of adrenomedullin (AM) and endothelin-1 (ET-1) in the adaptation of the maternal vascular system in normotensive pregnancy. Methods: Twenty-eight pregnant women, who were normotensive throughout the duration of their pregnancy, were recruited into the study. Plasma levels of AM and ET-1 at each trimester were measured and the AM/ET-1 ratio was calculated. Results: Our experiment showed a significant decrease in plasma concentrations of AM in the first trimester for the study group (n=28) compared with the non-pregnant control group (n=16). There was also a significant decrease in plasma concentrations of ET-1 in all three trimesters (P < 0.05) and a significant increase in the AM/ET-1 ratio in all three trimesters (P < 0.05) for the study group compared with the control group. Conclusion: An alteration in vascular equilibrium between AM and ET-1, favouring AM, may be a reason why the physiological adaptation of the maternal vascular system to pregnancy occurs during normotensive pregnancy.eninfo:eu-repo/semantics/closedAccessadrenomedullinadrenomedullin/endothelin-1 ratioendothelin-1pregnancythree trimestersArticle25436737410.1007/s12325-008-0041-y2-s2.0-5814932733418463805Q1WOS:000255873700007Q4