Öğden, MustafaBakar, BülentAltunkaya, CananDağlı, Ahmet TuranÖzdemir, AlemiddinÖzveren, Mehmet Faik2025-01-212025-01-2120192148-9645https://doi.org/10.24938/kutfd.531788https://search.trdizin.gov.tr/tr/yayin/detay/415113https://hdl.handle.net/20.500.12587/23070Objective: In the current literature, there are few acceptedpharmacological treatment methods for acute ischemic stroke.This study was conducted to investigate the effects ofprogesterone on transient ischemia / reperfusion injury in malerats.Material and Methods: A total of 25 Wistar albino male andyoung rats were divided into 5 groups called Control group,acute stage groups (Sham-A and PRG-A), and chronic stagegroups (Sham-C and PRG-C), randomly and their internalcarotid arteries were compressed using temporary aneurysmclips for 30 minutes. At 4 hours after removal of the clips,progesterone was injected to the animals of the PRG-A andPRG-C group via intraperitoneal route. After sacrifice of allanimals, pyknotic and necrotic neuronal cells were counted inhippocampal cornu amnonis (CA)1, CA2, CA3 and parietalcortical regions, histopathologically. Tissue interleukin (IL)-6,IL-10, caspase-3, and hypoxia-inducible factor-1 (HIF1) geneexpression levels were evaluated using real time polymerasechain reaction assay.Results: Histopathological and biochemical findings revealedthat progesterone has no healing effects on ischaemic neuronaltissue damage in either acute or chronic period. Moreover,progesterone was found to significantly increase symptoms ofischaemia in both acute and chronic periods compared tohealthy control group and even compared to Sham groups whereI/R injury was applied and no experimental agent wasadministered.Conclusion: At the end of this study, it was thought thatprogesterone had no therapeutic effect on cerebral ischemia /reperfusion injury in male sex rats and it could lead to increase itfurther, unfortunately.eninfo:eu-repo/semantics/openAccessTıbbi Araştırmalar DeneyselEndokrinoloji ve MetabolizmaNörolojik BilimlerFizyolojiArticle21218319410.24938/kutfd.531788415113