Cesur, SemraYucel, AykanNoyan, VolkanSagsoz, Nevin2020-06-252020-06-252012Cesur, S., Yucel, A., Noyan, V., & Sagsoz, N. (2012). Plasma lipocalin-2 levels in pregnancy. Acta obstetricia et gynecologica Scandinavica, 91(1), 112–116.0001-6349https://doi.org/10.1111/j.1600-0412.2011.01158.xhttps://hdl.handle.net/20.500.12587/5391Yucel, Aykan/0000-0002-5888-692XObjective. To evaluate plasma levels of lipocalin-2, which is a novel adipokine associated with obesity and insulin resistance, in pregnant women. Design. Prospective casecontrol study. Setting. University hospital. Population. Pregnant women with pre-pregnancy body mass index >25kg/m2 (overweight; n=29) and body mass index <25kg/m2 (n=27), whose gestational ages were between 24 and 28weeks, as study groups and nonpregnant control women with body mass index <25kg/m2 (n=29). Methods. Plasma lipocalin-2 levels, fasting plasma glucose and fasting plasma insulin levels; homeostasis model assessment insulin resistance index and fasting plasma glucose/fasting plasma insulin ratio were measured for each subject. Main Outcome Measures. Comparisons among the groups and correlations for lipocalin-2 and the parameters of insulin resistance. Results. Plasma lipocalin-2 levels among the pregnant women were significantly higher than those of the control group (p<0.001 for both group comparisons). Lipocalin-2 levels were significantly higher in the group with pre-pregnancy body mass index >25kg/m2 compared with the group with pre-pregnancy body mass index <25kg/m2 (p=0.003). Lipocalin-2 levels were positively correlated with homeostasis model assessment insulin resistance index and fasting plasma insulin and negatively correlated with fasting plasma glucose/fasting plasma insulin ratio in both pregnant groups. Conclusions. Lipocalin-2 was found to be higher in pregnant women, especially when pre-pregnancy body mass index was >25kg/m2, and it was correlated with markers of insulin resistance.eninfo:eu-repo/semantics/openAccessLipocalin-2insulin resistancepregnancyoverweightArticle91111211610.1111/j.1600-0412.2011.01158.x2-s2.0-8345522542721504415Q1WOS:000297922200018Q2