Tuglu, D.Yuvanc, E.Ozan, T.Bal, F.Yilmaz, E.Atasoy, P.Batislam, E.2020-06-252020-06-252016closedAccess0303-45691439-0272https://doi.org/10.1111/and.12499https://hdl.handle.net/20.500.12587/6513KISA, Ucler/0000-0002-8131-6810; Batislam, Ertan/0000-0002-7493-4573The aim of this study was to investigate the antioxidant properties of udenafil citrate (1.4 mg kg(-1)-2.8 mg kg(-1)), dexmedetomidine 25 mu g kg(-1) and piracetam 200 mg kg(-1) administered on ipsilateral/contralateral testes after ischaemia in a rat model of testicular torsion/detorsion (T/D) and define its protective effect histologically. Fifty-six Wistar albino rats were included and randomly assigned into 6 groups. No intervention was performed in control group (Group 1, n = 8) and in torsion/detorsion group, (Group 2, n = 8). Udenafil 1.4 mg kg(-1) was given to torsion/detorsion group (Group 3, n = 10), udenafil 2.8 mg kg(-1) was given to torsion/detorsion group (Group 4, n = 10), piracetam 200 mg kg(-1) was given to torsion/detorsion group (Group 5, n = 10) and dexmedetomidine 25 mu g kg(-1) was given to torsion/detorsion group (Group 6, n = 10) intraperitoneally after 60 mins of testicular torsion. Biochemical and histopathological testicular injury were evaluated. When the tissue was examined by TOS values, Group 3, Group 4 and Group 5 were significantly lower than Group 2. In contrary Group 6 values were significantly higher than Group 2. The increasing doses of udenafil demonstrated antioxidant properties on the testis tissue and histopathological that protects the testicles.eninfo:eu-repo/semantics/closedAccessDexmedetomidinepiracetamtotal antioxidant capacity (TAC)total oxidant status (TOS)udenafilArticle48667668210.1111/and.124992-s2.0-8497753243026589469Q1WOS:000380894600010Q3