Pehlivanli, FarukAgalar, FatihAgalar, CananSaygun, OralDaphan, CagatayAydinuraz, KuzeySahiner, Tayfun2020-06-252020-06-252011Pehlivanlı, F., Ağalar, F., Ağalar, C., Saygun, O., Daphan, Ç. E., Aydınuraz, K., Büyükkoçak, Ü., Çağlayan, O., Dom, S., Şahiner, İ. T. (2011). The value of CRP, IL-6, leptin, cortisol, and peritoneal caspase-3 monitoring in the operative strategy of secondary peritonitis. Ulusal Travma ve Acil Cerrahi Dergisi, 17(5), 390 - 395.1306-696Xhttps://doi.org/10.5505/tjtes.2011.03443https://hdl.handle.net/20.500.12587/4951Sahiner, Ibrahim Tayfun/0000-0002-3921-7675BACKGROUND We aimed to investigate the impact of C-reactive protein (CRP), interleukin (IL)-6, leptin, cortisol, and caspase-3 on the decision of terminating planned abdominal repair in secondary peritonitis. METHODS Fifteen patients with peritonitis were enrolled into the study. Serum CRP, IL-6, leptin, cortisol, and peritoneal caspase-3 activities were measured. RESULTS APACHE II scores at 48 hours (h) and age were significantly higher in non-survivors. A significant decrease was observed in caspase-3 activities of patients in whom <= 4 laparotomies were performed when compared with those who underwent >4 laparotomies. For patients who underwent <= 4 laparotomies, there was a significant difference in caspase-3 levels between 0 and 72 h. There was no significant difference in caspase-3 levels in non-survivors; caspase-3 levels were significantly lower in the survivors at 48 and 72 h. Changes in CRP, IL-6, leptin, and cortisol levels were not statistically significant. CONCLUSION CRP, IL-6, leptin, cortisol, and caspase-3 are not valuable in discriminating the number of planned operations, even though there is a significant decrease in caspase-3 "within" survivors. The discriminative value of caspase-3 for closure should be evaluated in studies in which caspase-3 is monitored for a longer duration in a large number of patients.eninfo:eu-repo/semantics/openAccessCaspase-3peritonitisplanned relaparotomyinterleukin-6cortisolArticle17539039510.5505/tjtes.2011.034432-s2.0-8005403170022090322Q3126990WOS:000295901400003Q4