Kirdag, Mustafa KorayTuglu, DevrimYuvanc, ErcanKisa, UclerBalci, MahiBatislam, ErtanYilmaz, Erdal2020-06-252020-06-252019closedAccess2149-32352149-3057https://doi.org/10.5152/tud.2018.22556https://hdl.handle.net/20.500.12587/7644Objective: In this study, we aimed to investigate the antioxidant effects of selenium and coenzyme Q on renal damage in a partial unilateral ureteral obstruction (PUUO) in a rat model. Material and methods: A total of 24 Sprague-Dawley rats were divided into four groups as Group 1 Control Group, Group 2, PUUO Group, Group 3 PUUO + coenzyme Q group, Group 4 PUUO + selenium group. Paraoxonase (PON), total antioxidant capacity (TAC), and total oxidant levels (TOS) were analyzed biochemically from tissue and blood samples. Tissue samples were examined histopathologically. Results: The TAC in the tissues was found to be statistically significantly increased in Groups 3 and 4, compared to Group 2. Tissue TOS was found to be significantly reduced in Groups 3 and 4, compared to Group 2. Serum PON levels were significantly increased in Group 3 and 4, compared to Group 1 and 2. Histopathological examination showed that interstitial inflammation and congestion were lesser in the coenzyme Q and selenium groups than in the PUUO group. A more significant decrease was found in the selenium group than in the coenzyme Q group. Conclusion: Our study results showed that coenzyme Q and selenium reduced the oxidation and the damage in tissue in PUUO in rats.eninfo:eu-repo/semantics/closedAccessCoenzyme Qkidneyoxidative stress indexparaoxonasepartial unilateral ureteral obstructionseleniumtotal antioxidant capacitytotal oxidant statusArticle45707710.5152/tud.2018.225562-s2.0-8507786294330461382N/A537050WOS:000502637300013N/A