Tursun, SerkanAlpcan, AysegulErgur, Ayca TorelKarahan, IrfanNeselioglu, SalimErel, Ozcan2021-01-142021-01-142020Tursun S, Alpcan A, Ergur AT, Karahan I, Neselioglu S, Erel O. (2020). Does Subclinical Hypothyroidism Affect Dynamic Thiol / Disulfide Homeostasis and İschemia-modified Albumin Levels in Children?. J Coll Physicians Surg Pak; 30(7):726-729.1022-386X1681-7168https://doi.org/10.29271/jcpsp.2020.07.726https://hdl.handle.net/20.500.12587/12649karahan, irfan/0000-0003-4669-1751Objective: To determine the effects of subclinical hypothyroidism on oxidative stress in children. Study Design: A cross-sectional study. Place and Duration of Study: Department of Paediatrics, Paediatric Endocrinology, and General Outpatient Clinics, Kirikkale University, School of Medicine, from May 2017 to October 2018. Methodology: This study included 92 subjects aged between 2 and 18 years. The subjects were divided into two groups. Forty-seven children with subclinical hypothyroidism and 45 healthy controls were evaluated. In order to evaluate oxidative damage, native thiol, total thiol, disulfides, their ratios, and ischemia-modified albumin (IMA) levels were compared between the two groups. The relationship between TSH and IMA levels was assessed. Results: Age and gender were not significantly different in the two groups. Native thiol, total thiol, disulfides and their ratios were similar in the two groups. lschemia-modified albumin levels were significantly higher in the patient group than the controls (p<0.001). There was no correlation between TSH and IMA levels in the patient group (r=0.069 p=0.645). Conclusion: Subclinical hypothyroidism may be related to the impairment of IMA, and have a neutral effect on thiol/disulfide balance. Further research is needed to explain the effects of oxidative stress in subclinical hypothyroidism.eninfo:eu-repo/semantics/openAccessSubclinical hypothyroidismChildhoodOxidative stressArticle30772672910.29271/jcpsp.2020.07.7262-s2.0-8508964717532811603Q2WOS:000561256500010Q4