Öğden, MustafaYüksel, UlaşAkkaya, SüleymanOppong, JonathanKısa, ÜçlerBakar, BülentÖzveren, Mehmet Faik2025-01-212025-01-2120192548-0251https://doi.org/10.21601/ortadogutipdergisi.431357https://search.trdizin.gov.tr/tr/yayin/detay/401094https://hdl.handle.net/20.500.12587/22622Aim: Diffuse idiopathic skeletal hyperosteosis (DISH) characterized by formation of disseminated osteofites on vertebra in the absence of traumatic or post infectious changes is a chronic disease of unknown etiology. This study was aimed to investigate the biochemical relationship of DISH in patients with DISH.Material and Method: Eleven patients diagnosed with DISH (DIH group) and eleven patients with axial pain but without any vertebral disease (Control group) who applied to the neurosurgery clinic between the years 2016-2017 were enrolled in this retrospective study. HLA-B27 antigen positivity, erythrocyte sedimentation rate, leukocyte, basofil and eosinophil counts, C-reactive protein, phosphorus and calcium levels, and their results in individuals were investigated. Anteroposterior and lateral pelvis, knee, lateral foot radiograms showing extra-axial involvement were viewed.Results: Of the patients with DISH, one owing to difficulty in swallowing and another owing to quadriplegia as a result of cervical trauma underwent surgical therapy. Radiological investigations of this group revealed iliac involvement in four patients and patellar joint involvement in one patient. There was no difference between groups with respect to age, sex, leucocyte, basophil and eosinophil count, C-reactive protein, phosphorus and calcium levels. However there was a significant difference with respect to dysphagia and extra-axial involvement. No individual was positive for HLA-B27 antigen.Conclusion: Present study findings suggested that both acute and/ or chronic inflammatory processes have no place in the etiology of this disease.eninfo:eu-repo/semantics/openAccessGenel ve Dahili TıpSağlık Bilimleri ve HizmetleriRomatolojiArticle11210711310.21601/ortadogutipdergisi.431357401094