Erer, DilekOzer, AbdullahDemirtas, HuseyinGonul, Ipek IsikKara, HalilArpaci, HandeKucuk, Aysegul2020-06-252020-06-252016Erer, D., Özer, A., Demirtaş, H., Gönül, İ. I., Kara, H., Arpacı, H., Çomu, F. M., Oktar, G. L., Arslan, M., & Küçük, A. (2016). Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia-reperfusion injury in rats. Drug design, development and therapy, 10, 2651–2658.1177-8881https://doi.org/10.2147/DDDT.S110529https://hdl.handle.net/20.500.12587/6719Arslan, Mustafa/0000-0003-4882-5063Objectives: To evaluate the effects of alprostadil (prostaglandin [PGE1] analog) and iloprost (prostacyclin [PGI2] analog) on renal, lung, and skeletal muscle tissues after ischemia reperfusion (I/R) injury in an experimental rat model. Materials and methods: Wistar albino rats underwent 2 hours of ischemia via infrarenal aorta clamping with subsequent 2 hours of reperfusion. Alprostadil and iloprost were given starting simultaneously with the reperfusion period. Effects of agents on renal, lung, and skeletal muscle (gastrocnemius) tissue specimens were examined. Results: Renal medullary congestion, cytoplasmic swelling, and mean tubular dilatation scores were significantly lower in the alprostadil-treated group than those found in the I/R-only group (P<0.0001, P=0.015, and P<0.01, respectively). Polymorphonuclear leukocyte infiltration, pulmonary partial destruction, consolidation, alveolar edema, and hemorrhage scores were significantly lower in alprostadil- and iloprost-treated groups (P=0.017 and P=0.001; P<0.01 and P<0.0001). Polymorphonuclear leukocyte infiltration scores in skeletal muscle tissue were significantly lower in the iloprost-treated group than the scores found in the nontreated I/R group (P<0.0001). Conclusion: Alprostadil and iloprost significantly reduce lung tissue I/R injury. Alprostadil has more prominent protective effects against renal I/R injury, while iloprost is superior in terms of protecting the skeletal muscle tissue against I/R injury.eninfo:eu-repo/semantics/openAccessalprostadililoprostischemia reperfusion injuryratrenallungskeletal muscleArticle102651265810.2147/DDDT.S1105292-s2.0-8498590612227601882Q1WOS:000382210800001Q2