Yıldırım, EnginDerici, Mehmet KürşatSimsek, Omer YavuzDemir, Emre2020-06-252020-06-252019Yıldırım, E., Derici, M. K., Şimşek, O. Y., Demir, E. (2019). Is there a relationship between serum kisspeptin levels and endometrial polyps in women with premenopausal status. Annals of Medical Research, 26(7), 1253 - 1257.2636-76882636-7688https://doi.org/10.5455/annalsmedres.2019.04.216https://app.trdizin.gov.tr/publication/paper/detail/TXpFM01ERXlNZz09https://hdl.handle.net/20.500.12587/1581Aim: Endometrial polyps are frequently associated with abnormal uterine bleeding. The kispeptin family is one of the peptidesthat play a role in reproductive functions and whose expression varies in various uterine pathologies. The aim of the study was todetermine the relationship between serum Kisspeptin levels and endometrial polyps in women with premenopausal status.Material and Methods: The blood was collected prior to endometrial sampling from women admitted to the hospital due to abnormaluterine bleeding. According to the pathology results, patients were identified as polyp group (n38) (endometrial polyps) and controlgroup (n50) (normal endometrial findings). Kisspeptin-54 levels were determined by ELISA method from serum obtained fromvenous blood.Results: There were no difference was found between the patients’ age, body mass index, gravida, para, abortus and the numberof living children were compared (p0.05). There was no statistically significant difference between the groups in terms of folliclestimulating hormone, luteinizing hormone and thyroid stimulating hormone values (p0.05). Plasma kisspeptin (1.840.93 ng/dLand 1.320.47 ng/dL, p 0.008) and estradiol (90.3413.02 pg/mL and 81.7512.36 pg/mL, p0.002) levels were significantly higherin the polyp group than in the control group. After the Receiver Operating Characteristic (ROC) analysis the area under the curve(AUC) was 1.26 (p 0.08), (95% CI, 0.550-0.782). The sensitivity value was 0.684 (0.512-0.819), the specificity was 0.620 (0.471-0.750).Conclusion: The serum Kisspeptin-54 and estradiol levels were found higher in patients with endometrial polyps.eninfo:eu-repo/semantics/openAccessBiyolojiDiş HekimliğiAlerjiAnatomi ve MorfolojiAndrolojiAnesteziOdyoloji ve Konuşma-Dil PatolojisiBiyokimya ve Moleküler BiyolojiBiyofizikBiyoteknoloji ve Uygulamalı MikrobiyolojiKalp ve Kalp Damar SistemiHücre BiyolojisiKlinik NörolojiYoğun Bakım, TıpDermatolojiAcil TıpEndokrinoloji ve MetabolizmaGastroenteroloji ve HepatolojiGeriatri ve GerontolojiSağlık Bilimleri ve HizmetleriHematolojiİmmünolojiEnfeksiyon HastalıklarıTamamlayıcı ve Entegre TıpTıbbi EtikTıbbi İnformatikTıbbi Laboratuar TeknolojisiGenel ve Dahili TıpAdli TıpTıbbi Araştırmalar DeneyselMikrobiyolojiNörolojik BilimlerKadın Hastalıkları ve DoğumOnkolojiGöz HastalıklarıOrtopediKulak, Burun, BoğazPatolojiPediatriPeriferik Damar HastalıklarıFizyolojiTemel Sağlık HizmetleriPsikiyatriHalk ve Çevre SağlığıRadyoloji, Nükleer Tıp, Tıbbi GörüntülemeRehabilitasyonSolunum SistemiRomatolojiSpor BilimleriCerrahiTransplantasyonTropik TıpÜroloji ve NefrolojiFarmakoloji ve EczacılıkToksikolojiArticle2671253125710.5455/annalsmedres.2019.04.216317012