Üreten, KemalÖztürk, M. AkifBostancı, AhmetÇeneli, ÖzcanÖzbek, MustafaHaznedaroğlu, İbrahim C.2020-06-252020-06-252010Ureten, K., Ozturk, M. A., Bostanci, A., Ceneli, O., Ozbek, M., & Haznedaroglu, I. C. (2010). Atraumatic osteonecrosis after estrogen replacement therapy associated with low protein S level in a patient with Turner syndrome. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 16(5), 599–601. https://doi.org/10.1177/10760296093397461076-0296https://doi.org/10.1177/1076029609339746https://hdl.handle.net/20.500.12587/4651Haznedaroglu, Ibrahim C./0000-0001-8028-9462; Haznedaroglu, Ibrahim C./0000-0001-8028-9462Atraumatic osteonecrosis has been associated with a variety of clinical conditions including corticosteroid usage, alcoholism, infections, hyperbaric events, storage disorders, marrow-infiltrating diseases, coagulation defects, and some autoimmune diseases. Osteonecrosis due to thrombophilia is an extremely rare condition with only few cases reported previously in the literature. Hormone-replacement therapies cause increased risk of venous thrombosis, probably by causing a synergistic effect with inherited clotting defects. In this article, we report a young female with Turner syndrome, who developed avascular necrosis of the femoral head during treatment with oral estrogen, which was associated with low protein S levels.eninfo:eu-repo/semantics/openAccessosteonecrosisprotein S deficiencyestrogenArticle16559960110.1177/10760296093397462-s2.0-7795586855519648147Q2WOS:000281079400018Q3