Akanbong, ElishaDevrim, Alparslan KadirŞenol, AliDevrim, Tuba2025-01-212025-01-2120211300-74162602-2109https://doi.org/10.17343/sdutfd.971047https://search.trdizin.gov.tr/tr/yayin/detay/502549https://hdl.handle.net/20.500.12587/23075Cytokine release syndrome (CRS) or cytokine storm is as a result of the excess production of pro-inflammatory cytokines which is due to the disproportionate response of the immune system which can be instigated by SARS-CoV-2. COVID-19 which is caused by SARSCoV- 2 has a correlation with cytokines. SARSCoV- 2 instigates the production of IL-1 by ubiquitous macrophages and mast cells. IL-1 tends to influence the production of IL-6 and TNF-?. The progression of COVID-19 severity influences the level of certain cytokines such as IL-6. IL-6 is the cytokine chiefly responsible for the occurrence of CRS. CRS is the cause of COVID-19-related complications and the main cause of COVID-19-related deaths. Despite the data reported in the literature so far, the relationship between SARS-CoV-2 and cytokines has not been fully elucidated. The aim of the present review is to examine the relationship in question. Targeting cytokines during COVID-19 treatment has the potential to increase patient survival and reduce COVID-19-related deaths. It is concluded that focusing on the mechanisms of cytokine release and the effects of released cytokines, especially examining the effects on T lymphocytes and IFN-? production in COVID-19 disease, may help reduce the lethal effects of the disease.eninfo:eu-repo/semantics/openAccessTıbbi Araştırmalar DeneyselGenel ve Dahili TıpBiyokimya ve Moleküler BiyolojiİmmünolojiReview Article28468769410.17343/sdutfd.971047502549